Transforming Asthma Pathways – End Of Programme Statement: 30/03/2023

Transforming asthma care through improved access to diagnostics and innovative treatments

Asthma is a common health condition, affecting more than 5.4 million people in the UK. Uncontrolled, severe asthma has a huge impact on the lives of 200,000 UK patients, including frequent emergency hospital admissions and serious side-effects from extended periods on steroid medication.

As a key partner of NHS England’s Accelerated Access Collaborative (AAC), the Health Innovation Network Network has supported the rollout of two asthma care innovations to improve the asthma pathway in England as part of the AAC Rapid Uptake Products (RUP) programme.

Fractional exhaled Nitric Oxide (FeNO) testing. FeNO testing is a simple, non-invasive test to measure the amount of nitric oxide in an exhaled breath – a biomarker for airway inflammation. FeNO testing can improve patient care by contributing to a faster and more effective asthma diagnosis when used alongside a detailed clinical history and other tests. It can also be used to monitor patient response to asthma treatments.

Biologic therapies for patients with severe asthma. Asthma biologics work in a targeted way, by disrupting pathways causing airways inflammation, helping to manage symptoms and reduce exacerbations. These therapies can transform patients’ lives by reducing long-term side effects of other treatments, such as steroids, and reduce the number of life-threatening asthma attacks.

In 2020, it was noted that both innovations had lower-than-expected patient access, presenting an opportunity to improve uptake and support the NHS Long Term Plan ambition of improving early and accurate diagnosis of respiratory conditions by embedding FeNO testing in primary care and increasing access to asthma biologics through improved clinical pathways.

Led by Oxford Health Innovation Network (Asthma Biologics) and Wessex Health Innovation Network (FeNO), the programmes focused on collaboration at a national, regional and local level across healthcare systems, industry partners, patients, and the community and voluntary sector to integrate FeNO testing and access to asthma biologics into everyday clinical practice.

Health Innovation Networks worked within their individual systems to support asthma pathway improvements by taking a pathway-based transformation approach. Health Innovation Networks provided clinical and transformation leadership, shared best practice and developed education and implementation materials for those involved in providing asthma care.

A package of educational resources for each innovation, including information documents, podcasts, posters, learning modules and webinars, was created to support clinicians. The toolkits were designed in a practical way to support teams adopting and sustaining the use of FeNO and asthma biologics.

Next Steps

The national FeNO and Asthma Biologics programmes have now completed and have made substantial contributions to the transformation of asthma care in England while significantly increasing the access to and adoption of FeNO and asthma biologics. Learning from the Health Innovation Network programmes is being fed into the development of NICE/SIGN/British Thoracic Society asthma guidance, expected in 2024, offering real world insights to implementation considerations.

There are opportunities to continue this work and improve asthma care by enhancing rollout of the innovations and ensure more patients can benefit. Both toolkits, training modules and other resources created during the programmes will remain accessible to NHS clinicians following the end of the Health Innovation Network programmes.

The Health Innovation Network Network is now transitioning to support healthcare inequalities as a national priority as part of NHS England’s Innovation for Healthcare Inequalities Programme (InHIP). Building on the transforming asthma pathways work, a number of Health Innovation Networks will support the respiratory aspect of the NHS England Core20PLUS5 approach, continuing to utilise the implementation and educational resources developed for the  FeNO and Asthma Biologics national programmes.


The programmes aimed to improve patient care and outcomes through enhanced access to diagnostics and treatments for severe asthma. The full impact of the programmes is still being finalised however interim data shows that between April 2021 and February 2023:

  • An estimated 190,818 additional patients benefited from diagnostic FeNO testing across England.
  • More than 4,403 new patients began receiving life-changing biologic therapies.
  • 3,157 fewer patients are now receiving high-dose (3g or more) oral steroids each month.
  • 41 Pathway Transformation Fund projects were completed to support wider adoption of asthma biologics and FeNO

For the clinical workforce delivering asthma care the programme has supported learning, training and development.

  • More than 4,300 hours of specialist training was delivered to upskill those providing asthma care.
  • 1,750 people attended webinars and learning collaboratives related to asthma biologics and FeNO.
  • Online resource toolkits for asthma biologics and FeNO have been accessed more than 28,000 times.
  • The asthma consensus pathway was launched, providing a new set of standards based on best practice to guide how to deliver optimal care across the entire patient journey.

Programme benefits

Child-Parent Screening offers an equitable approach to FH identification and can detect up to 90% of affected people. One study found that for every 1,000 children screened, eight people (four children and four adults) were identified as having FH, and could begin potentially life-saving medication and/or lifestyle and dietary changes.

Without treatment, FH can lead to heart disease at a young age. Identifying affected individuals before the onset of disease is important because treatments can be put in place that promote a healthy, active lifestyle and lower blood cholesterol levels, all of which substantially reduce the risk of heart disease.

Where a child is identified as having FH, parents, siblings and grandparents can also be tested as necessary, potentially identifying full families who have the condition. Age appropriate medication and advice can then be offered to families to reduce the risk of cardiac disease.


Project team

Anisha Leith

Rabia Gowa

Related Projects